Adverse side-effects from prescription drugs are not at all rare. In fact, many drugs routinely cause very serious adverse side-effects, often very much more serious than the health problems for which they are taken. Only take them if they are really necessary and take them in the lowest effective dose.
Get informed about the harm drugs do. – For a start you could read about tricyclic antidepressants like amitriptyline here:
and about steroids like prednisolone or HRT here: