Leptin may be going to raise its ugly head again...)o:

Failed obesity wonder drug Leptin revived by new research
article in the Telegraph

Extract:

"Leptin, an appetite-suppressing hormone, was greeted with great excitement more than a decade ago with many academics believing that it could be a cure for obesity.

But hopes soon dimmed when it was found that overweight people became unresponsive to Leptin very quickly due to the development of resistance in the brain.

Now its reputation could be revived after researchers have found a way to stop the brain blocking its influence.

Scientists at Harvard University have found that the substances Buphenyl (4-PBA) and Tauroursodeoxycholic acid (TUDCA), both available in pills, stop the brain from ignoring Leptin.

Their findings, published in Cell Metabolism, suggest that it once again could help the growing weight problem around the world.

"Everyone in the field thought they would get the Nobel," said Dr Umut Ozcan, who led the study, about the period when Leptin was first discovered."

Overweight people do NOT need appetite suppressants to lose weight. - They need to reduce their problem of fluid retention/salt sensitivity to lose weight. They need to be told the truth. - Eating less food/fewer calories actually encourages weight gain, not weight loss. - Here is information about how overweight people can lose excess weight safely, quickly and very easily indeed, without taking dodgy pharmaceutical junk:

Lose weight safely, reduce your risk of most cancers, high blood pressure, type 2 diabetes, stroke, heart disease, heart attack, vascular dementia, osteopenia, osteoporosis, hypercholesterolaemia, depression, liver and kidney problems, and improve your health in many other ways without drugs, hunger or expense by eating less salt! - Try it! - You will feel so much better!

Read my Mensa article on Obesity and the Salt Connection

And see Sodium in foods and

http://www.wildeaboutsteroids.co.uk/story.html - my 'political' page

http://www.wildeaboutsteroids.co.uk/socio.html - social and economic considerations

amitriptyline

prescribed steroids and HRT

See advice for pregnant mothers

Children and Obesity

Associated health conditions

and FAT RETENTION

I can be contacted via my website if you need my further help. My help is free.

Misguided scientists claim to have found the hormone to stop over-eating. - They are proposing more pharmaceutical junk drugs to mimic leptin.

Scientists find hormone to stop over-eating - Telegraph

Extract:

"A new class of drugs to treat obesity could be developed within a decade after a study of a hormone that stops us eating too much.

Those who lack the chemical, called leptin, find less appetising food such as broccoli as mouthwatering as chocolate cake. The result is that they over-eat even when they are not hungry.

Although the hormone is well known to influence appetite by signalling how much fat is in the body, a study today shows that it also controls emotional attachment to food.

The research suggests that it should be possible to design anti-obesity drugs which interfere with the brain's "pleasure" centres - the regions that respond to rewarding emotions and desires.

Leptin has been intensively studied since it was discovered in 1994. But several years ago it was found that injections of the hormone are ineffective as an anti-obesity treatment.

Today's work, published in the journal Science by Dr Sadaf Farooqi and Dr Paul Fletcher of Addenbrooke's Hospital, Cambridge, will boost research since it shows that drugs that can mimic leptin's effects in the part of the brain that governs our food cravings could offer a treatment for obesity.

Dr Farooqi said that such drugs are already being studied and, if effective, would over-ride brain signals that regulate hunger. The drugs would not turn people off food but make them more discriminating."

It's such a shame/scandal that researchers waste time and money on stuff like this. - The assumption behind all this twaddle is that obesity is caused by eating too much - eating too many calories. - This assumption is not supported by evidence and has never even been subjected to trial. - Pharmaceutical drugs that alter the brain in some way are clearly not a desirable route to take in tackling obesity. - It is the body that is functioning abnormally in obese people, not the brain. - And the fundamental abnormality in the body of an obese person is the state of the veins. - When the veins have been weakened by high salt intake in childhood, or when the veins have been weakened by a high salt intake during pregnancy or by salt intake when taking prescribed steroids/corticosteroids like prednisone (AKA Deltasone) or prednisolone (AKA Prelone, Pediapred), HRT, tricyclic antidepressants like amitriptyline (AKA elavil, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline, Laroxyl) or many other prescription drugs, then the bloodstream becomes suffused with excess salt/sodium and excess water that the salt attracts to itself. See http://www.wildeaboutsteroids.co.uk/steroids.html and http://www.wildeaboutsteroids.co.uk/ami.html

This excess fluid in the bloodstream leads inevitably to weight gain. There are various names for the condition - salt sensitivity, sodium retention, fluid retention, hypervolemia, obesity, water retention. - Doctors and obesity 'experts' fail to understand the etiology of obesity because they consistently disregard the evidence their obese patients give them.

Obesity is caused by fluid retention, not by overeating.

Fortunately, it is extremely easy to reduce the fluid retention and therefore the obesity. - Sodium is the vector holding the excess water in the bloodstream, so reducing sodium intake releases some of the excess water and it is excreted in the urine.

Sometimes fat retention follows fluid retention, especially if people try to lose weight by dieting and therefore are eating insufficient food, leading (significantly) to insufficient calcium, magnesium and vitamin D. - If you increase your intake of these, you will excrete some of the excess fat in the faeces. - It is not necessary, or even desirable, to eat a low fat diet. See http://aboutsalt.blogspot.com/search/label/calcium and BBC webpage about calcium from The Truth About Food series of programmes

Lose weight by eating less salt! Go on! - Try it! - You will feel so much better!
How to Lose weight!

See my website http://www.wildeaboutsteroids.co.uk/.html
(The site does not sell anything and has no banners or sponsors or adverts - just helpful information.)

Read my Mensa article on Obesity and the Salt Connection

See Sodium in foods and

Associated health conditions and

http://www.wildeaboutsteroids.co.uk/story.html - my 'political' page

http://www.wildeaboutsteroids.co.uk/socio.html - social and economic considerations

I can be contacted via my website if you need my further help. My help is free.